ceesdekker.net Secrets
ceesdekker.net Secrets
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Rotary movement of DNA rotors on nanopores. Prime row: raw online video in the Cy5 channel of each rotor. Center row: corresponding single-particle localization effects of the two finishes in the DNA rotors. The position of the current body is marked as orange and blue dots, along with the trajectory of The ten frames just before The existing frame is demonstrated as strong strains.
Human Rad51 filaments on double- and solitary-stranded DNA: correlating frequent and irregular varieties with recombination perform.
Multicolor imaging with the bacterial nucleoid and mobile division proteins with blue, orange, and close to-infrared fluorescent proteins
Because 2000, Dekker has shifted the primary target of his perform in direction of biophysics in which he scientific studies the Houses of solitary biomolecules and cells using the resources of nanotechnology. This transformation of field was pushed by his fascination with the extraordinary performing of Organic molecular structures, in addition to by the long-time period point of view that lots of intriguing discoveries could be expected During this subject.[five] Existing lines of investigate in his biophysics team are inside the areas of:[six]
We acquire stage-of-treatment diagnostics test of neglected tropical health conditions in just resource-confined options, depending on Crspr/Cas9 detecting of pathogen’s DNA in physique fluids.
Cornelis (Cees) Dekker (Haren, seven april 1959) is een Nederlandse natuurkundige en universiteitshoogleraar verbonden aan de Technische Universiteit Delft. Van 2010 tot en achieved 2018 was hij tevens directeur van het Kavli Institute of Nanoscience in Delft. Zijn vakgebied is de moleculaire biofysica; hierbij beweegt hij zich op het grensvlak van de natuurkunde en de biologie waarbij hij gebruikmaakt van de zogeheten nanotechnologie, de technieken om aan enkele atomen en moleculen te kunnen meten.
All parameters were the identical for each panel In this particular movie, aside from the Original placement of the 6hb rod (shown in blue) around the nanopore. Simulations that terminated early on account of translocation on the rod from the pore are marked by a gray qualifications.
2011, initially in vitro measurements of transportation across a single biomimetic nuclear pore elaborate; enhancement of multiplexed magnetic tweezers for kilo-molecule experiments; and solved the mechanism of homology recognition in DNA homologous recombination
‘You shouldn't just contemplate the issues of tomorrow, but will also evaluate the issues with the working day soon after tomorrow’
Dekker begun his exploration on single carbon nanotubes in 1993 when he arrange a different line of analysis to study electrical transportation via one natural molecules concerning nanoelectrodes. In 1996 a breakthrough was recognized with carbon nanotubes. This was achieved in a very collaboration With all the team of Nobel laureate Richard Smalley. STM and nanolithography tactics were accustomed to demonstrate that these nanotubes are quantum wires at The only-molecule level, with remarkable physical Houses.
Because 2000 he moved to solitary-molecule biophysics and nanobiology, with research from scientific tests of DNA loop extrusion and supercoiling to DNA translocation via nanopores. Far more recently his analysis has centered on researching chromatin structure and cell division with micro organism on chip, while he is additionally aiming to ultimately Construct artificial cells from The underside up.
Cees Dekker is Distinguished University Professor at TU Delft. Educated as a physicist, he pioneered nanotechnology with a lot of discoveries on carbon nanotubes inside the nineteen nineties. Considering that 2000, he moved to solitary-molecule biophysics and nanobiology. https://www.ceesdekker.net His latest analysis concentrates on (i) nanopores for protein sequencing; (ii) chromosome composition, especially SMC motor protein; and (iii) developing a living synthetic cell from lifeless molecules. Dekker is definitely an elected member from the KNAW and fellow into the APS as well as IOP.
2008, 1st observation of protein-coated DNA translocation by means of nanopores; resolved the origin of the electrophoretic drive on DNA in nanopores; found an important velocity raise of microtubules in electrical fields; found an anomalous electro-hydrodynamic orientation of microtubules; and fixed the origin of sounds in carbon nanotubes in liquid
2013, managed shaping of Reside bacterial cells into arbitrary styles; and discovery of spontaneous fluctuations in the handedness of histone tetrasomes